Shape-IVF

Fertility in women depends on many factors such as weight, smoking, eating habits, working conditions, but mostly has to do with age changes that are the catalysts of pregnancy.

The control steps made quickly, securely include:


  • hormonal control of ovarian function in the early days of the cycle. This check will show the adequacy and quality of follicles
  • transvaginal ultrasound to determine the quantitative ovarian function but also the anatomy of the uterus and endometrium
  • salpingografia to highlight possible tubal pathology and
  • cycle monitoring and assessment of the time of ovulation (ultrasonography, hormones or ovulation urine).

The frequency and duration of sexual contacts and, of course, the quality of sperm, which can be easily determined with 1-2 sperm, must be taken seriously

When the couple fails to achieve a pregnancy within a reasonable time (6-9 months) and if the above checks have revealed no pathology for some of which a relevant therapeutic intervention is needed, then you need a medical support, which could be:


  • induction of the multiple ovulation and contact (TSI)
    This treatment is carried out using hormonal preparations for the production of 3-4 eggs, and calculation of the appropriate time determined by the sonographic findings together with hormonal measurements made throughout the duration of therapy to the woman.
  • Intrauterine Insemination (IUI)
    This technique was successfully applied to couples in which the above factors have made a reproductive system healthy with suboptimal sperm, even in cases of unexplained infertility. In these cases, the presence of multiple eggs after ovarian stimulation and laboratory preparation of sperm and its implantation into the uterus, increase the pregnancy rates. It is because they allow the sperm to easily reach the edge of trumpets, where the insemination takes place, having the energy and the number of eggs needed for this purpose.
    Although, the process could be done in the natural cycle of women, with an egg that is produced naturally during a month time, the drug stimulation of the ovaries produce more eggs and greatly increases the chance of pregnancy. Stimulation is simply clomiphene citrate pills, injections of follicle stimulating hormone or combination of both. The injections are simple and are done subcutaneously by the women themselves.
    The monitoring of ovarian stimulation is performed with transvaginal ultrasound and hormonal measurements throughout the duration of stimulation. The installation is not the seed of intrauterine and intrafallopian, making it more efficient. Success rates are low, around 15%. This is the reason that this technique is not proposed to older women because they would have "wasted" precious egg that would have, theoretically, been used at IVF to achieve a better result.

Also, repeating the treatment more than three times is pointless . It is due to the failure of achieving a pregnancy that usually refers to saplingiki dysfunction. Even if the salpingografia of the trumpets seemed normal, the problems in the sperm, despite some improvement of the preotoimasia, did not allow the eggs to enter, thus leading to fertilization and conception.

The big disadvantages of IUI is inability to evaluate the quality of eggs, as opposed to IVF, and the risk of ectopic pregnancy in cases of tubal dysfunction.



  • IVF (IVF)
    IVF is the most effective technique in assisted reproduction because it:

  • bypasses the fallopian tubes and general pelvic problems
  • controls the quality of the eggs
  • treats sperm problems in most cases of male infertility
  • allows the creation of embryos in the laboratory and finally
  • selects the number, quality and the time of transfer into the uterus by giving the possibility of preimplantation control in cases of gene diseases or pathologies related eggs/ semen.

Embryo transfer is a simple procedure that is usually carried out without anesthetic intervention after cleansing the vagina and cervix.

The embryos are placed in a catheter tip of inert and very soft teflon and transferred into the uterus under control with abdominal ultrasound.

According to the existing legislation, it is permitted to place 3 embryos (women ≤ 40 years) or 4 embryos (women ≥ 40 years) to avoid multiple pregnancies.

This technique is widely applied with a great safety and success rates ranging to 40%.

Although it could be applied to an egg during a natural cycle, in cases of ovarian failure, history of malignancy or in peri-menopausal women, it is more effective after an ovarian stimulation and retrieval of multiple eggs. In this way, it allows to create multiple embryos implying options such as quality, freezing and future use, pregnancy rates and avoid repeating the treatment.

Ovarian stimulation is more intense and allows monitoring of the treatment closely. The therapy involves the use of subcutaneous injections of follicle stimulating hormone, so that the ovaries produce 10-15 eggs. During the treatment, that is usually done within 10-12 days, vaginal ultrasound and hormonal measurements are done in women. When the ovarian follicles reach 18-20 mm, then they become artificially ripe and, consequently, retrieved. This procedure is performed vaginally under sedation and intravenous anesthetic monitoring. The time does not exceed 10-15 minutes, and the recovery is fast without any problems. The side effects of medication relate to an ovarian hyperstimulation, while the transfer of 3 embryos could lead to triplet pregnancies related problems.

Although hormonal preparations have occasionally been contempted by the media for a potential fear of future risk of malignancy in ovaries and breast. However, until now, these fears have not been scientifically confirmed. As in all medical practices including IVF, the guarantee of safety of the couple and the effectiveness of the technique should be respected all.



  • IVF ICSI (IVF/ICSI)
    If the sperm cannot fertilize the egg in the laboratory, despite its preparation and activation, then after a suitable treatment, spermatozoa is injected into every available egg (intracytoplasmic sperm injection = ICSI) for this purpose.

This process is required in cases such as:


  • Severe oligo-patient-teratozoospermia
  • obstructive or secretory azoospermia when sperm gets from the epididymis or testis - previous fertilization failure
  • unexplained infertility with failure of other assisted reproduction techniques.

The technique is purely laboratory and the process of ovarian stimulation, monitoring, and oocyte retrieval are the same as in simple IVF.

Donor’s Eggs

Unfortunately, pregnancy is not a privilege of all, as there are women who want to have children, but fail because of:


  • premature ovarian failure in women under the age of 35
  • qualitative disturbance of eggs
  • old age (women over 45)
  • genetic (chromosomal) lesions and hereditary diseases that can be passed to the fetus
  • low ovarian productivity due to chemotherapy, radiation, and surgery or endometriosis treatments at an earlier age.

The solution for these cases is a donor’s egg. It is a popular process that is legally regulated, anonymous and has a great success rate, more than 60%, in our country. Mandatory thorough checks are carried out on donors in order to make the process extremely safe.


The process is based on two pillars:

  • The donor receives an injection treatment for the egg production
  • The recipient takes estrogen and progesterone to prepare the uterus for embryos created from the donor’s eggs and the sperm of recipient’s partner.

The embryo transfer procedure is simple and is carried out with the help of ultrasound. The results in our country are excellent and can be compared to those of other big units abroad. The waiting time is small due to the availability of sufficient donors’ eggs.